IGF-1 DES: Comprehensive Research Guide

Overview

IGF-1 DES (Des(1-3)IGF-1) is a truncated form of insulin-like growth factor-1 that lacks the first three amino acids (Glu-Pro-Glu). This modification reduces binding to IGF binding proteins (IGFBPs), resulting in increased bioavailability and enhanced potency compared to standard IGF-1.

Mechanism of Action

Enhanced Bioavailability

• Reduced Binding: Less binding to IGF binding proteins
• Increased Free IGF-1: Higher levels of free, active IGF-1
• Potency: 10-100x more potent than standard IGF-1
• Receptor Binding: Direct binding to IGF-1 receptors

Anabolic Effects

• Muscle Growth: Promotes muscle protein synthesis
• Cell Proliferation: Stimulates cell growth and division
• Recovery: Enhances recovery and repair
• Glucose Uptake: Improves glucose uptake into cells

Research Applications

Muscle Growth Research

• Hypertrophy: Research into muscle growth
• Recovery: Enhanced recovery from exercise
• Performance: Research into athletic performance
• Aging: Research into age-related muscle loss

Metabolic Research

• Glucose Metabolism: Research into glucose control
• Insulin Sensitivity: Improves insulin sensitivity
• Fat Metabolism: May affect fat metabolism

Dosage

• Research: 10-50 mcg daily
• Typical: 20-30 mcg
• Administration: Subcutaneous or intramuscular
• Timing: Post-workout or before bed

Side Effects

• Hypoglycemia: Low blood sugar risk
• Injection Site: Reactions at injection site
• Headache: Possible headaches
• Organ Growth: Theoretical risk of organ enlargement

Storage

• Temperature: -20°C (frozen)
• Light: Protect from light
• Stability: Requires careful storage

This information is for research and educational purposes only.