Neurotensin: Comprehensive Research Guide

Overview

Neurotensin is a 13-amino acid neuropeptide that plays important roles in the central nervous system and gastrointestinal tract. It is involved in pain modulation, dopamine regulation, gastrointestinal function, and various other physiological processes.

Mechanism of Action

Receptor Binding

• **NTS1 Receptors': Binds to NTS1 receptors
• **NTS2 Receptors': Binds to NTS2 receptors
• **NTS3 Receptors': Binds to NTS3 receptors
• **Multiple Functions': Diverse physiological effects

Physiological Roles

• **Pain Modulation': Modulates pain perception
• **Dopamine': Regulates dopamine release
• **GI Function': Regulates gastrointestinal function
• **Reward': Plays roles in reward pathways

Research Applications

Neurological Research

• **Schizophrenia': Research into schizophrenia
• **Pain': Research into pain mechanisms
• **Dopamine': Research into dopamine regulation
• **Addiction': Research into addiction mechanisms

GI Research

• **GI Function': Research into gastrointestinal function
• **GI Disorders': Research into GI conditions

Dosage

• **Research': Dose-dependent, protocols vary
• **Administration': Intracerebroventricular or intranasal
• **Half-Life': Short half-life

Side Effects

• **Hypotension': Possible low blood pressure
• **Research Only': Research use only

This information is for research and educational purposes only.