Nociceptin: Comprehensive Research Guide

Overview

Nociceptin (also known as Orphanin FQ) is an endogenous 17-amino acid peptide that is structurally similar to opioids but produces effects opposite to traditional opioids. It binds to the NOP (nociceptin/orphanin FQ peptide) receptor and plays roles in pain modulation, anxiety, and various other processes.

Mechanism of Action

NOP Receptor Activation

• **NOP Receptors': Binds to NOP (ORL1) receptors
• **Hyperalgesia': Can produce hyperalgesia (increased pain sensitivity)
• **Anxiety': Can produce anxiety-like effects
• **Opposite Effects': Effects opposite to traditional opioids

Physiological Roles

• **Pain Modulation': Modulates pain perception
• **Anxiety': Plays roles in anxiety regulation
• **Reward': Involved in reward pathways
• **Stress': Plays roles in stress responses

Research Applications

Pain Research

• **Pain Mechanisms': Research into pain pathways
• **Hyperalgesia': Research into hyperalgesia mechanisms
• **Chronic Pain': Research into chronic pain conditions

Behavioral Research

• **Anxiety': Research into anxiety disorders
• **Stress': Research into stress responses
• **Addiction': Research into addiction mechanisms

Dosage

• **Research': Dose-dependent, protocols vary
• **Administration': Intracerebroventricular
• **Half-Life': Short half-life

Side Effects

• **Hyperalgesia': Can increase pain sensitivity
• **Anxiety': Can produce anxiety
• **Research Only': Research use only

This information is for research and educational purposes only.