Sermorelin: Comprehensive Research Guide

Overview

Sermorelin (GHRH 1-29) is a synthetic analog of growth hormone-releasing hormone. It consists of the first 29 amino acids of the natural 44-amino acid GHRH molecule. Sermorelin stimulates the pituitary gland to produce and release growth hormone in a natural, pulsatile pattern.

Mechanism of Action

Growth Hormone Release

• Pituitary Stimulation: Binds to GHRH receptors on pituitary somatotrophs
• Natural Pattern: Promotes pulsatile GH release (mimics natural secretion)
• Feedback Loop: Works with natural feedback mechanisms
• Selective: More selective than direct GH administration

Advantages Over Direct GH

• Natural Pattern: Maintains natural GH pulsatility
• Feedback: Preserves negative feedback loops
• Safety: Lower risk of side effects
• Diagnostic: Can be used to test pituitary function

Research Applications

Growth Hormone Deficiency

• Diagnosis: Used to test GH secretion capacity
• Treatment: Approved for GH deficiency treatment
• Aging: Research into age-related GH decline
• Recovery: May support recovery and healing

Anti-Aging Research

• GH Restoration: Restores GH levels in aging individuals
• Body Composition: Improves lean mass and reduces fat
• Sleep: May improve sleep quality
• Energy: Increases energy levels

Dosage Protocols

Standard Protocol

• Dose: 100-300 mcg daily
• Typical: 200 mcg before bedtime
• Timing: Best administered before sleep (when GH naturally peaks)
• Administration: Subcutaneous injection

Cycle Recommendations

• Duration: 3-6 months
• Cycles: 3 months on, 1 month off
• Monitoring: Regular GH and IGF-1 testing recommended

Side Effects

• Minimal: Generally well-tolerated
• Injection Site: Mild irritation possible
• Headache: Occasional headaches
• Dizziness: Rare dizziness
• No Acromegaly: Lower risk than direct GH

Storage

• Temperature: 2-8°C (refrigerated)
• Light: Protect from light
• Reconstituted: Use within 2-3 weeks

This information is for research and educational purposes only. Sermorelin is a prescription medication.