Argireline
Acetyl Hexapeptide-8 • Acetyl Hexapeptide-3
Mechanism
Cosmetic peptide that inhibits neurotransmitter release, reducing muscle contractions that cause wrinkles. Mimics the N-terminal end of SNAP-25 protein.
Half-Life
Topical
Administration
Technical Protocol
Argireline: Comprehensive Research Guide
Overview
Argireline (Acetyl Hexapeptide-8) is a synthetic peptide widely used in cosmetic formulations for its anti-wrinkle properties. It works by inhibiting neurotransmitter release, which reduces muscle contractions responsible for expression lines and wrinkles.
Mechanism of Action
Neurotransmitter Inhibition
- SNAP-25 Mimic: Mimics the N-terminal end of SNAP-25 protein
- Synaptic Blockade: Prevents vesicle fusion and neurotransmitter release
- Muscle Relaxation: Reduces facial muscle contractions
- Wrinkle Reduction: Diminishes expression lines
Cosmetic Benefits
- Fine Lines: Reduces appearance of fine lines
- Wrinkles: Diminishes wrinkle depth
- Expression Lines: Targets dynamic wrinkles
- Prevention: May prevent new wrinkle formation
Research Applications
Skincare
- Anti-Aging: Reduces signs of aging
- Wrinkle Treatment: Topical wrinkle reduction
- Cosmetic Formulations: Used in serums and creams
- Combination Therapy: Often combined with other peptides
Dosage
- Topical: 5-10% solution in cosmetic formulations
- Application: Twice daily to affected areas
- Duration: Results visible after 2-4 weeks
Side Effects
- Minimal: Generally well-tolerated
- Skin Irritation: Possible mild irritation
- Allergic: Rare allergic reactions
This information is for research and educational purposes only.
Peer-Reviewed Citations
Acetyl hexapeptide-8 (Argireline) in cosmetic formulations
Blanes-Mira C, et al. • Int J Cosmet Sci (2002)
Access ResearchFrequently Asked Questions
What is Argireline?
A popular cosmetic peptide used in anti-aging skincare products. Reduces fine lines and wrinkles by inhibiting muscle contractions.
How does Argireline work?
Cosmetic peptide that inhibits neurotransmitter release, reducing muscle contractions that cause wrinkles. Mimics the N-terminal end of SNAP-25 protein.
What is the typical dosage of Argireline in research?
The typical research dosage of Argireline is 5-10% solution (range: Topical application). Common administration routes include Topical.
How should Argireline be stored?
Store at room temperature, protect from light
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