Secretin: Comprehensive Research Guide

Overview

Secretin is a 27-amino acid peptide hormone produced in the duodenum. It was the first hormone ever discovered (1902) and plays important roles in regulating pancreatic secretion and gastric acid production.

Mechanism of Action

Pancreatic Function

• **Bicarbonate Secretion': Stimulates pancreatic bicarbonate secretion
• **Pancreatic Enzymes': May affect enzyme secretion
• **Neutralization': Neutralizes acidic chyme from stomach

Gastric Function

• **Acid Inhibition': Inhibits gastric acid secretion
• **Gastric Motility': May affect gastric motility
• **Digestion': Supports digestive processes

Research Applications

Medical Applications

• **Diagnostic': Used in diagnostic tests (pancreatic function)
• **Pancreatic Disorders': Research into pancreatic conditions
• **GI Disorders': Research into GI conditions

Research

• **Digestive Physiology': Research into digestive processes
• **Hormone Research': Historical significance in endocrinology

Dosage

• **Diagnostic': Dose varies by test protocol
• **Administration': Intravenous
• **Half-Life': Short half-life (3-5 minutes)

Side Effects

• **Minimal': Generally well-tolerated
• **GI Effects': Possible GI effects

This information is for research and educational purposes only. Secretin is a prescription medication.