Substance P: Comprehensive Research Guide

Overview

Substance P is an 11-amino acid neuropeptide belonging to the tachykinin family. It functions as both a neurotransmitter and a neuromodulator, playing important roles in pain transmission, inflammation, mood regulation, and various physiological processes.

Mechanism of Action

Neurotransmission

• Pain Transmission: Transmits pain signals in the nervous system
• Neurotransmitter: Acts as a neurotransmitter in the CNS
• Neuromodulator: Modulates other neurotransmitter systems
• Receptor Binding: Binds to NK1 receptors

Physiological Roles

• Inflammation: Involved in neurogenic inflammation
• Mood: Plays roles in mood and stress
• Immune Function: Modulates immune responses
• GI Function: Regulates gastrointestinal function

Research Applications

Pain Research

• Pain Management: Research into pain treatment
• Chronic Pain: Research into chronic pain conditions
• Neuropathic Pain: Research into neuropathic pain
• Inflammation: Research into inflammatory conditions

Neurological Research

• Mood Disorders: Research into depression and anxiety
• Stress: Research into stress responses
• **Neurodegeneration': Research into neurodegenerative diseases

Dosage

• Research: Dose-dependent, protocols vary
• Administration: Intranasal, subcutaneous, or topical
• **Frequency': Varies by research protocol

Side Effects

• Flushing: Possible flushing
• **Hypotension': Low blood pressure possible
• **Bronchospasm': Possible breathing difficulties
• **GI Effects': Possible gastrointestinal effects

Storage

• **Temperature': -20°C (frozen)
• **Light': Protect from light
• **Stability': Requires careful storage

This information is for research and educational purposes only.