Teriparatide: Comprehensive Research Guide

Overview

Teriparatide (Forteo) is a synthetic form of parathyroid hormone (PTH) consisting of the first 34 amino acids of the natural 84-amino acid hormone. It is approved for the treatment of osteoporosis and works by stimulating new bone formation, unlike most osteoporosis medications that prevent bone loss.

Mechanism of Action

Bone Formation

• Osteoblast Activity: Stimulates osteoblast (bone-building cell) activity
• Bone Growth: Promotes new bone formation
• Bone Density: Increases bone mineral density
• Bone Quality: Improves bone microarchitecture

Anabolic vs. Antiresorptive

• Anabolic: Builds new bone (unlike antiresorptives that prevent loss)
• Unique: Only anabolic osteoporosis treatment
• Temporary: Limited to 2 years of use
• Effectiveness: More effective than antiresorptives for severe osteoporosis

Research Applications

Osteoporosis Treatment

• Postmenopausal: Treatment of postmenopausal osteoporosis
• Men: Treatment of osteoporosis in men
• Fracture Risk: Reduces fracture risk
• Bone Density: Increases bone mineral density

Bone Healing

• Fracture Healing: Research into fracture healing
• Bone Grafts: Research into bone graft incorporation
• Non-Union: Research into non-union fractures

Dosage

• Standard: 20 mcg daily
• Administration: Subcutaneous injection
• Duration: Maximum 2 years (due to osteosarcoma risk in rats)
• Timing: Can be taken at any time of day

Side Effects

• Common: Nausea, dizziness, leg cramps, headache
• Hypercalcemia: Possible elevated calcium levels
• Osteosarcoma: Theoretical risk (seen in rats, not humans)
• Duration Limit: Limited to 2 years of use

Storage

• Temperature: 2-8°C (refrigerated)
• Do Not Freeze: Protect from freezing
• After First Use: Can be stored at room temperature for up to 28 days

This information is for research and educational purposes only. Teriparatide is a prescription medication.