Dulaglutide
Trulicity
Mechanism
Long-acting GLP-1 receptor agonist providing sustained glucose control and weight management with once-weekly dosing.
Half-Life
5 days
Administration
Technical Protocol
Dulaglutide: Comprehensive Research Guide
Overview
Dulaglutide (Trulicity) is a long-acting GLP-1 receptor agonist designed for once-weekly administration. Its extended half-life of approximately 5 days provides sustained glucose control and makes it one of the most convenient diabetes medications available.
Mechanism of Action
- GLP-1 Receptor Agonism: Activates GLP-1 receptors throughout the body
- Insulin Secretion: Enhances glucose-dependent insulin release
- Glucagon Suppression: Reduces glucagon secretion
- Gastric Emptying: Delays gastric emptying
- Appetite: Promotes satiety and reduces food intake
Research Applications
Type 2 Diabetes
- Glycemic Control: Significant HbA1c reduction
- Cardiovascular Benefits: Reduces major adverse cardiovascular events
- Weight Management: Promotes weight loss
- Convenience: Once-weekly dosing improves adherence
Dosage
- Starting: 0.75 mg once weekly
- Maintenance: 1.5 mg once weekly
- Maximum: 4.5 mg once weekly
- Administration: Subcutaneous injection, any day of week
Side Effects
- GI Effects: Nausea, diarrhea, vomiting
- Hypoglycemia: Low risk when used alone
- Pancreatitis: Rare but serious
This information is for research and educational purposes only. Dulaglutide is a prescription medication.
Peer-Reviewed Citations
Dulaglutide and cardiovascular outcomes in type 2 diabetes
Gerstein HC, et al. • Lancet (2019)
Access ResearchFrequently Asked Questions
What is Dulaglutide?
A once-weekly GLP-1 receptor agonist approved for type 2 diabetes treatment. Provides sustained glucose control with convenient weekly dosing.
How does Dulaglutide work?
Long-acting GLP-1 receptor agonist providing sustained glucose control and weight management with once-weekly dosing.
What is the typical dosage of Dulaglutide in research?
The typical research dosage of Dulaglutide is 1.5-4.5 mg (range: 0.75-4.5 mg). Common administration routes include Subcutaneous.
How should Dulaglutide be stored?
Store at 2-8°C, do not freeze
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