GLP-2: Comprehensive Research Guide

Overview

Glucagon-Like Peptide-2 (GLP-2) is a 33-amino acid peptide hormone produced in the intestine. It plays crucial roles in promoting intestinal growth, enhancing nutrient absorption, and maintaining gut barrier function. It is approved for the treatment of short bowel syndrome.

Mechanism of Action

Intestinal Growth

• **Mucosal Growth': Promotes intestinal mucosal growth
• **Villus Height': Increases villus height
• **Crypt Depth': Increases crypt depth
• **Surface Area': Increases absorptive surface area

Nutrient Absorption

• **Absorption': Enhances nutrient absorption
• **Transport': Improves nutrient transport
• **Digestion': Supports digestive processes

Gut Barrier

• **Barrier Function': Maintains gut barrier integrity
• **Permeability': Reduces intestinal permeability
• **Protection': Protects against bacterial translocation

Research Applications

Medical Applications

• **Short Bowel Syndrome': Approved treatment for SBS
• **Intestinal Disorders': Research into intestinal conditions
• **Malabsorption': Research into malabsorption syndromes

Research

• **Intestinal Growth': Research into intestinal development
• **Nutrient Absorption': Research into absorption mechanisms

Dosage

• **Medical': Dose varies by condition (teduglutide formulation)
• **Research': Dose-dependent, protocols vary
• **Administration': Subcutaneous injection
• **Half-Life': Short half-life (7 minutes)

Side Effects

• **Nausea': Possible nausea
• **Abdominal Pain': Possible abdominal pain
• **Headache': Possible headaches
• **GI Effects': Possible GI effects

This information is for research and educational purposes only. GLP-2 is available as teduglutide, a prescription medication.